Aluminum Phosphate Catalyzed Free Solvent Preparation of β-enamino Esters
نویسندگان
چکیده
منابع مشابه
A Solvent-free Synthesis of β-Enamino Trihalomethyl Ketones
Este trabalho apresenta uma metodologia, ambientalmente adequada e mais econômica em relação àquelas descritas na literatura, para a obtenção de uma série de vinte e seis 4-amino1,1,1-trialo-3-alquen-2-onas [CX3C(O)CH=C(R 1)NR2R3, com X = F, Cl, R1 = H, Me, e R2/R3 = H/Ph, H/4-F-Ph, H/Bn, H/(CH2)2OH, Me/Ph, Me/Bu, Et/Et, -(CH2)4-], a partir da reação de 1,1,1-trialo-4-alcóxi-3-alquen-2-onas com...
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Uma série de cetonas e ésteres α,β-insaturados β-amino ésteres, 4a-h e 6a-d, derivados de α-amino ácidos foi obtida a partir dos cloridratos dos α-amino ésteres 2a-d e dos compostos 1,3-dicarbonílicos 3a,b e 5 em presença de trietilamina. Estes compostos foram preparados empregando energia de microondas, sem uso de solvente, utilizando como suporte sólido K-10 ou KSF e também foram efetuadas re...
متن کاملA Chemoselective Route to β-Enamino Esters and Thioesters
Conditions were developed for syntheses of β-enamino esters, thioesters, and amides. These reactions involve hydroxybenzotriazole derivatives in buffered media. Illustrative syntheses of some heterocyclic systems are given, including some related to protein-protein interface mimics.
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A novel synthetic approach to functionalized indolo[2,3-a]quinolizidines is developed via an N-heterocyclic carbene (NHC)-catalyzed annulation of cyclic β-enamino esters with enals . This methodology offers a pathway for quick and efficient construction of an indolo[2,3-a]quinolizidine skeleton which is a core structure of many natural products with diverse bioactivities.
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IBX facilitated the reaction of β-enamino esters with allylic alcohols affording a direct, one-pot and metal free synthesis of functionalized pyridines including 2-substituted nicotinic acids, densely substituted pyridines and precursors of azafluorenones. The methodology also afforded the racemic pyridine core of cyclothiazomycin.
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ژورنال
عنوان ژورنال: American Journal of Chemistry
سال: 2012
ISSN: 2165-8749
DOI: 10.5923/j.chemistry.20120205.05